Signal Transduction Reagents and Kits
Enzo Life Sciences BAY 61-3606. hydrochloride (1mg). CAS: 648903-57-5
Cell permeable, potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC50=10nM). Highly selective if compared to other kinases; shows no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src up to concentrations of 4.7µM. Anti-inflammatory and orally active. Exhibits good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models. Alternative name: 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide . HCl. Purity: ≥98% (HPLC(UV)). Appearance: Yellow solid. Solubility: Soluble in water (30mg/ml), DMSO (2mg/ml) or methanol (1mg/ml). Long Term Storage: -20°C.
Medchemexpress LLC Syk-IN-1 | 1491150-77-6 | 99.18% | 100 MG
Syk-IN-1 is a potent Syk inhibitor, with an IC50 of 35 nM. It is intended for research use only.
- Potent Syk inhibitor with an IC50 of 35 nM.
- Offered as a solid for various research applications.
- Optimal storage for powder: -20°C for 3 years or 4°C for 2 years.
- Optimal storage for solvent: -80°C for 6 months or -20°C for 1 month.
Enzo Life Sciences 8-Bromo-cGMP (50mg). CAS: 51116-01-9
A cell-permeable cGMP analog which is more resistant to phosphodiesterases than cGMP and which preferentially activates cGMP-dependent protein kinase. It inhibits thrombin stimulated arachidonic acid release in human platelets. Purity: ≥96% (HPLC). Solubility: Soluble in water (25mg/ml) or aqueous buffers. Sparingly soluble in methanol (4mM). Insoluble in DMSO, dimethyl formamide and 96% ethanol. Long Term Storage: -20°C.
Echelon Biosciences Research Labs PI(3,4)P2 PolyPIPosomes 0.1 mL
PolyPIPosomes are polymerized liposomes that show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents. PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PIP. Each order of 250 L or 1 mL of PolyPIPosomes includes 100 L of Control PolyPIPosomes. This item is non returnable
Echelon Biosciences Research Labs 1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP) 10 mg
1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP or HMBPP) is an intermediate in the non-mevalonate pathway and is biosynthesized from 2-C-Methyl-D-erythritol 2,4-cyclophosphate (cMEPP) by IspG (GcpE). It is the substrate for IspH (LytB) yielding IPP and DMAPP. In addition, HDMAPP is the most potent VgVd T-cell activator identified. This item is non returnable
Apexbio Technology LLC Calpain and cathepsin B inhibitor, selective 88191-84-8. MFCD28137700
Calpain and cathepsin B inhibitor, selective 88191-84-8. MFCD28137700
Meso Scale Discovery Phos Tyr694TTL STAT5ab WCL 5
The Meso Scale Discovery Phospho-Tyr694/Total STAT5A/B Whole Cell Lysate Kit (K15163D) is a kit for detecting phosphorylated STAT5A/B and total STAT5A/B in cell lysates The kit contains a 96-well plate coated with capture antibodies against STAT5A/B and phospho-STAT5A/B Tyr694 It also includes detection antibodies and buffers needed to perform the assay The electrochemiluminescent detection allows for high sensitivity and a broad dynamic range This kit can be used to monitor STAT5A/B phosphorylation and activation in response to cytokines growth factors and drugs that modulate the JAK/STAT pathway It requires a low amount of sample and provides high-quality data
Enzo Life Sciences Salubrinal (5mg). CAS: 405060-95-9
Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC50~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (BML-CC104)). Purity: ≥98% (HPLC(UV)). Appearance: White to off-white powder. Solubility: Soluble in DMSO (300 mg/ml), dioxane (0.5 mg/ml), methanol (5 mg/ml) or acetonitrile (1.5 mg/ml). Long Term Storage: -20°C.
Aat Bioquest Cal-590™ AM | 5x50ug
Calcium measurement is critical for numerous biological investigations. Fluorescent probes that show spectral responses upon binding calcium have enabled researchers to investigate changes in intracellular free calcium concentrations by using fluorescence microscopy, flow cytometry, fluorescence spectroscopy and fluorescence microplate readers. Rhod-2 is most commonly used among the red fluorescent calcium indicators. However, Rhod-2 AM is only moderately fluorescent in live cells upon esterase hydrolysis, and has very small cellular calcium responses. Cal-590™ has been developed to improve Rhod-2 cell loading and calcium response while maintaining the spectral wavelength of Rhod-2, making it compatible with TRITC/Cy3 filter set. In CHO and HEK cells Cal-590™ AM has cellular calcium response that is much more sensitive than Rhod-2 AM.
Meso Scale Discovery Phospho-STAT3 (Tyr705) Kit, 96-well plate, 25 plates, detects STAT3 pTyr705, suitable for human, mouse, rat samples, compatible with various MSD instruments
The MESO SCALE DISCOVERY Phospho-STAT3 (Tyr705) Kit is designed as a rapid and convenient assay for the detection of STAT3 phosphorylated at tyrosine 705. The kit is suitable for research applications focused on phosphoproteins and intracellular signaling across various species, including human, mouse, and rat. Utilizing a 96-well plate format, it enables efficient processing of samples with high-throughput compatibility.
- Detects STAT3 phosphorylated at Tyr705, a crucial activation site.
- Validated for use with human, mouse, and rat samples.
- Compatible with multiple MSD instruments.
- Contains all essential reagents for accurate results.
- Includes comprehensive kit contents such as SULFO-TAG antibody and various buffers.
- Intended for research use only.
- Stored as multi-component modules.
Carnabio Usa Inc CK2A1/B(CSNK2A1/B)/10UG/FULL-L
CK2a1/b(CSNK2A1/B), Full-length(CK2a1), Wild type, Amino Acid 1-391(CK2a1), 1-215(CK2b), NP_001886.1(CK2a1), NP_001311.3(Ck2b1), Expressed in Insect (sf21); 10microg
Enzo Life Sciences Lysophosphatidic acid (25mg). CAS: 325465-93-8
Lysophosphatidic acid (LPA) is a multifunctional intercellular phospholipid messenger. LPA stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes. It acts as a proliferative and anti-apoptotic factor. Ligand for LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors. It also inhibits differentiation of neural stem cells into neurons. Alternative name: 1-Oleoyl-lysophosphatidic acid . sodium salt. Purity: ≥98% (TLC). Solubility: Soluble in water (5 mg/mL with sonication) or DMSO (0.5 mg/mL warm). Long Term Storage: -20°C.
Enzo Life Sciences 8-Bromo-cGMP (10mg). CAS: 51116-01-9
A cell-permeable cGMP analog which is more resistant to phosphodiesterases than cGMP and which preferentially activates cGMP-dependent protein kinase. It inhibits thrombin stimulated arachidonic acid release in human platelets. Purity: ≥96% (HPLC). Solubility: Soluble in water (25mg/ml) or aqueous buffers. Sparingly soluble in methanol (4mM). Insoluble in DMSO, dimethyl formamide and 96% ethanol. Long Term Storage: -20°C.
Medchemexpress LLC Reticuline | 485-19-8 | 329.39 | 1 MG
Reticuline exhibits anti-inflammatory effects by influencing JAK2/STAT3 and NF-κB signaling pathways. It inhibits the mRNA expression of TNF-α and IL-6, and reduces the phosphorylation levels of JAK2 and STAT3. Reticuline also demonstrates cardiovascular effects.
- Inhibits JAK2/STAT3 and NF-κB signaling pathways.
- Reduces TNF-α and IL-6 mRNA expression.
- Decreases JAK2 and STAT3 phosphorylation.
- Shows cardiovascular effects.
- Purity of 98.89%.
- Appearance: white to yellow solid.
- Soluble in DMSO.